Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine |
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Document Language |
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English |
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Abstract |
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Travel into outer space is fraught with risk of exposure to energetic heavy ion radiation such as 56Fe
ions, which due to its high linear energy transfer (high-LET) characteristics deposits higher energy per
unit volume of tissue traversed and thus more damaging to cells relative to low-LET radiation such as
γ rays. However, estimates of human health risk from energetic heavy ion exposure are hampered due
to lack of tissue specific in vivo molecular data. We investigated long-term effects of 56Fe radiation on
adipokines and insulin-like growth factor 1 (IGF1) signaling axis in mouse intestine and colon. Six- to
eight-week-old C57BL/6J mice were exposed to 1.6 Gy of 56Fe ions. Serum and tissues were collected up
to twelve months post-irradiation. Serum was analyzed for leptin, adiponectin, IGF1, and IGF binding
protein 3. Receptor expressions and downstream signaling pathway alterations were studied in tissues.
Irradiation increased leptin and IGF1 levels in serum, and IGF1R and leptin receptor expression in
tissues. When considered along with upregulated Jak2/Stat3 pathways and cell proliferation, our data
supports the notion that space radiation exposure is a risk to endocrine alterations with implications for
chronic pathophysiologic changes in gastrointestinal tract. |
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ISSN |
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2755-8773 |
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Journal Name |
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Scientific reports |
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Volume |
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6 |
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Issue Number |
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1 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, July 12, 2017 |
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Researchers
| Shubhankar Suman | Suman, Shubhankar | Researcher | Doctorate | |
| Santosh Kumar | Kumar, Santosh | Researcher | Doctorate | |
| Albert J. Fornace Jr. | Fornace Jr., Albert J. | Researcher | Doctorate | |
| Kamal Datta | Datta, Kamal | Researcher | Doctorate | kd257@georgetown.edu |
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